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ETHANOL EXTRACT OF TIKEN LEAVES (Fraxinus griffithii Clarke) AS ANTICONVULSANT IN MICE

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Title ETHANOL EXTRACT OF TIKEN LEAVES (Fraxinus griffithii Clarke) AS ANTICONVULSANT IN MICE
 
Creator Kirtishanti, AgusIina
Kartini, Indah
 
Subject R Medicine (General)
RS Pharmacy and materia medica
 
Description Tiken plants (Fraxinus griffithii Clarke) has been used as traditional medicine in Indonesia or other countries. Research has demonstrated that tiken bark extract may prolong barbiturate sleeping time and also have anticonvulsant effects in mice. This research was carried out using ethanol extract of tiken leaves to study its anticonvulsant effect in mice. The study used five groups of experimental animals. The groups consisted of one control group, three treatment groups, and one standard group. The control group was given CMC Na suspension, treatment groups were given ethanol extract of tiken leaves at doses of 4000,5000 and 6000 mg/kg body weight, respectively, the standard group was given Phenobarbital sodium solution at dose of 26 mg/kg body weight. Sixty minutes after treatment, all mice were induced using
electroshock induced seizures. Anticonvulsant effect was determined by reduction in seizure duration. There were statistically significant differences in seizure duration between treatment, standard, and control groups. It can be concluded that the ethanol extract of tiken - leaves have anticonvulsant effect in mice.
 
Publisher Fakultas Kedokteran dan Ilmu-Ilmu Kesehatan Universitas Jendral Soedirman
 
Contributor Sumarwati, Made
Laksana, Agung S. Dwi
Adi P., Tunggul
 
Date 2011-12
 
Type Book Section
PeerReviewed
 
Format application/pdf
application/pdf
application/pdf
 
Language en
en
en
 
Identifier /586/1/Kirtishanti_Ethanol%20Extract_Abstract_2011.pdf
/586/2/Kirtishanti_Ethanol%20Extract_2011.pdf
/586/3/Kirtishanti_Ethanol%20Extract_References_2011.pdf
Kirtishanti, AgusIina and Kartini, Indah (2011) ETHANOL EXTRACT OF TIKEN LEAVES (Fraxinus griffithii Clarke) AS ANTICONVULSANT IN MICE. In: Proceeding The First International Conference In Medicine And Health Sciences (ICMHS) 2011. Fakultas Kedokteran dan Ilmu-Ilmu Kesehatan Universitas Jendral Soedirman, Purwokerto, pp. 176-184. ISBN 978-602-19431-0-6